Elementsofpartialdifferentialequationsbyiansneddonpdffreedownload
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ElementsofpartialdifferentialequationsbyiansneddonpdffreedownloadAn evaluation of the effects of theophylline on urinary bladder isosmolarity in a dog model.
Although theophylline is an effective anti-dysuric drug, theophylline therapy has been associated with the occurrence of urinary tract stones. In this study, we investigated the intra-vesical capacity and isosmolarity of the hind-limb urinary bladder as a means of assessing the net positive effect of theophylline therapy. The thyro-coeliac branch of the ileocolic artery was ligated in six mongrel dogs. The bladder was emptied intermittently by clamping both ureters under general anesthesia. Bladder volume was estimated by measuring intra-vesical pressure with a water-filled catheter (size 20). Theophylline was administered as a continuous intravenous infusion via a jugular vein cannula at a rate of 0.5 mg/kg/min. Theophylline was administered on separate days, with and without simultaneous hypoosmolality (dilution) achieved by intravenous hypertonic saline (30 mOsm/kg). When the bladder was emptied intermittently, bladder volume was not significantly changed during theophylline infusion in either group. Theophylline decreased bladder pressure and increased bladder volume after the bladder had been emptied. Theophylline was equally effective with and without concurrent hypoosmolality. These results suggest that theophylline may, in fact, improve voiding efficiency without a net decrease in bladder volume, and that the risk of urinary bladder stone formation during theophylline therapy may not be related to the effect of theophylline on bladder isosmolarity.Q:
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